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KMID : 1094720150200010157
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Biotechnology and Bioprocess Engineering
2015 Volume.20 No. 1 p.157 ~ p.167
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Anti-hyperlipidemic and fat pad lowering effect of standardized tea seed cake extract in mice fed high-fat and high-carbohydrate diet
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Chaudhary Narendra
Bhardwaj Jyoti
Hwang Jae-Ho
Seo Hyo-Jin
Kim Min-Yong
Shin Tai-Sun
Wee Ji-Hyang
Shin Yu-Lim
Kim Jong-Deog
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Abstract
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Camellia sinensis L. O. Kuntze has traditionally been used in Asian countries as a stimulant, a diuretic, and to prevent obesity. Studies in green tea are well-documented in literature, though the potential of fruit from the plant has never been studied in details. In the present study, the anti-adipogenic effect of aqueous extract of green tea seed cake extract (GTE) were analysed in-vitro and the anti-obesity effects were determined in-vivo in murine model fed high-fat and high-carbohydrate diets. We found that GTE inhibited the lipid accumulation in 3T3-L1 adipocyte and significantly lowered body weight, body fat-pad weights, blood lipid, glucose, insulin, and leptin levels in mice fed high-fat and high-carbohydrate diets. GTE suppressed the expression of important adipogenic genes (PPARγ, C/EBPα, SREBP, LPL, aP2 and leptin) and lipid metabolism genes (FAS). Furthermore, GTE induced the levels of adiponectin in serum and adipose tissue, as well as AMP-activated protein kinase (AMPK) in liver tissue. These results suggested that GTE ameliorates its anti-obesity effect through multiple cells signaling pathways in diets induced obesity in mice.
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KEYWORD
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green tea seed cake, high-fat diet, high-carbohydrate diet, anti-obesity, adipose tissue, AMPK
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